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KMID : 0374919960170020177
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Inje Medical Journal
1996 Volume.17 No. 2 p.177 ~ p.184
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Immunohistochemical Assay of Androgen Receptor and Transforming Growth Factor-B in Colorectal Cancer
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Abstract
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Objectives:
@EN the prognosis of the advanced colorectal cancer is poor and effect of the conventional chemotherapy has not been satisfactory. This study is to explore the possibility of hormonal therapy or cytokine therapy by assaying hormone receptor and
cytokin
(androgen receptor and TGF-β), and their correlation with clinicopathologic parameters.
@ES Methods:
@EN Androgen receptor and TGF-β were assayed by immunohistochemical(IHS0 staining. The samples were prepared from surgical resection or biopsy. The correlation between the HIS postivity and clinical features or tumor differentiation were
assessed.
@ES Results:
@EN 1. The androgen receptor(AR) was negative in all 20 pt and TGF-βpositive in 10(50%) ; 6in 11 progesterone receptor positive patients(45%) and 4 in PR negative patients(36%0. There was no significant association between TGF-βpositivity and
the
age,
sex, tumorstage or CEA positivity at the time of diagnosis.
2. There was no significant correlation between TGF-β positivity and the age, sex, tumorstage or CEA positivity at the time of diagnosis
3. The histologic and nuclear differentiation(well, moderately and poorly differentiated) were not significantly different according to the status of the TGF-β positivity.
@ES Conclusions:
@EN This study first identified the TGF-β in colorectal cancer by immunohistological method in Korea. the androgen receptor was not positive. More study is needed to establish the role of the cytokine and hormone receptor in the pathogenesis and
treatment of colorectal cancer.
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KEYWORD
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